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KMID : 0604520230490010059
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Journal of the Society of Cosmetic Scientists of Korea
2023 Volume.49 No. 1 p.59 ~ p.65
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Identification of Antioxidant Activities and Stimulation of Human Keratinocytes Differentiation Effects of Syzygium claviflorum Extract
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Seo Ga-Yeon
Mon Ji-Yeon
Park Yu-Kyung
Kim Ju-Yeong
Hyun Ho-Yong
Jeong Beom-Su
Thet Thet Mar Win
Thant Zaw Win
Choi Sang-Ho
Eum Sang-Mi
Kim Dong-Won
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Abstract
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We validated the physiological activity of Syzygium claviflorum (Roxb.) Wall. ex A.M. Cowan & Cowan (S. claviflorum) extracts (leaves, stems, fruits, and flowers) as a cosmetic ingredient. Firstly, S. claviflorum extracts removed over 80% of free radicals at various concentrations in antioxidant experiments using the DPPH and ABTS assay. In cytotoxicity experiments using human epidermal keratinocytes, S. claviflorum extracts showed low cytotoxicity. In addition, S. claviflorum extracts significantly increased the expression of keratin (KRT)1, KRT2, KRT9, KRT10, which are differentiation markers of keratinocytes, as well as genes involved in the maintenance of skin barrier function, including involucrin (IVL), loricrin (LOR), filaggrin (FLG), and claudin1 (CLDN1). In particular, the expression of FLG protein, inhibited by interleukin (IL)-4/IL-13 in atopic dermatitis, was restored by S. claviflorum extracts in in vitro experiments. Therefore, S. claviflorum extracts with excellent antioxidant efficacy and skin barrier improvement function will be useful materials for the development of future atopic dermatitis treatments and cosmetics.
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KEYWORD
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Syzygium claviflorum, antioxidant, keratinocytes, filaggrin, atopic dermatitis
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